A World Where Patients No Longer Die
Waiting for Organ Transplants.
Or No More Lives Lost While Waiting For a Transplant

About

Senno Therapeutics is a biotech company dedicated to developing novel therapies for fatal liver failure using human iPS cell-derived liver progenitor cells and liver organoid technologies.
Senno was founded in 2024 based on iPS cell manipulation technologies developed at the Institute of Medical Science, the University of Tokyo.
We aim to deliver innovative cell therapies that offer patients with liver failure a lifesaving treatment option and alleviate complications from the critical shortage of donor organs.

Company Profile

Company Name
Senno Therapeutics Inc.
Representative
Chieko Mori, President and Representative Director
Established
June 2024
Capital
100,079,970 yen
Location
5-22-33 Higashi-Gotanda, Shinagawa-ku, Tokyo, Japan

Concept

The current reliance on organ transplantation for acute and chronic liver failure leaves a critical unmet need, with many patients dying each year due to the shortage of available organs. Innovative therapies that can address this gap represent a significant opportunity to transform patient outcomes.
Leveraging the iPSC bioengineering infrastructure and expertise developed over the past decade by Professor Hideki Taniguchi’s team at the Institute of Medical Science, the University of Tokyo, Senno is focused on developing cell therapies based on a process that enables the stable synthesis of human iPS cell-derived liver progenitor cells and liver organoids. Our goal is to make it possible for patients with liver disease to receive this potentially curative cell therapy at an early stage and in a minimally invasive manner.

The name “Senno” in Senno Therapeutics is inspired by Sen no Rikyu, a historical figure who established the Japanese tea ceremony. While traditional tea culture had once celebrated the lavish elegance of Chinese influence, Sen no Rikyu introduced a radically original aesthetic called wabi-sabi, which redefined the Japanese tea ceremony as a celebration of simplicity and imperfection.
This concept not only transformed the tea ceremony, but also redefined the spiritual and cultural essence of Japan – an influence which is still evident even today. Sen no Rikyu’s
transformative vision inspires us at Senno to work towards a similarly profound transformation in the treatment of liver disease. Like him, we seek to challenge convention, embrace innovation, and create lasting change by delivering hope and healing to patients who have long had limited options.

Science & Technology

We are discovering and developing novel cell therapies based on our technology platform and manufacturing processes for the stable production of human iPS cell-derived liver progenitor cells and liver organoids.

Team

  • Chieko Mori

    Representative Director and CEO

    Chieko Mori
    Profile
  • Hideki Taniguchi

    Scientific Founder and CSO

    Hideki Taniguchi
    Profile
  • Lisa Fox-Craig

    CTO

    Lisa Fox-Craig
    Profile
  • Keisuke Fujitaka

    Associate Director, Project Management

    Keisuke Fujitaka
    Profile
  • Yusuke Wada

    Corporate planning, Project Management

    Yusuke Wada
    Profile
Chieko Mori
Representative Director and CEO Chieko Mori

Chieko Mori began her career as a Pharmaceutical Technology Researcher at Astellas Pharma Inc. In 2010, she transitioned to the Portfolio Strategy Division, where she took on responsibilities related to business strategy. Subsequently, she served as the Strategic and Policy Secretary to the Global CEO of Astellas Pharma Inc. From 2017 to 2019, Chieko held the position of Vice President of Corporate Planning at Astellas US, where they were responsible for corporate strategy, governance, and regional business development.
Following this, she led global transactions in the Business Development Division at Astellas Pharma. In April 2024, she assumed the role of Chief Business Officer at Corundum Systems Biology Inc. In October 2024, she became the President and CEO of PhenoAI Japan Inc. In January 2025, she was appointed as the Representative Director and CEO of Sennose Therapeutics Inc.

Hikaru Saito
Board Hikaru Saito

Partner, Saisei Ventures
Hikaru Saito is a co-founder of Senno Therapeutics, bringing his expertise in building and expanding initial operations to realize Senno’s vision and realize a world where no more patients die waiting for a transplant.
Dr Saito has been a partner located in Tokyo Japan of Saisei Venture since 2023 and dedicating for creating companies by combination with Japan technologies and western ecosystems. Prior to Saisei, he was working at Astellas Pharma Inc, starting as a research scientist and spent over a decade R&D partnerships and biotechnology investments in the USA. Before Astellas, he was a visiting research fellow of the Institute of Medical Science, the University of Tokyo, JSPS research fellow.

Jonathan Yeh
Chairman & Board Jonathan Yeh

Managing Partner, Saisei Ventures
Jonathan is a co-founder and general partner of Saisei Ventures, a leading healthcare focused venture capital firm with operations in the United States and Japan. Jonathan is an early-stage investor focusing on biotechnology and advanced therapies, with particular expertise in the development of cell-based therapies and gene-modified cells. Jonathan’s diverse background spans early-stage venture company creation and investment, strategic business partnering, and fund management. He has co-founded several biotechnology companies and served in various board roles. Previously, Jonathan was a CIHR Post-doctoral Fellow at the IRIC.

Keisuke Fujitaka
Associate Director, Project Management Keisuke Fujitaka

Keisuke Fujitaka started his career as a pharmacology researcher at Mitsubishi-Tanabe Pharma Corporation. He has been involved in non-clinical research on renal, cardiovascular and metabolic diseases for about ten years. In 2018, he transitioned to Regenerative Medicine Development Division of Mitsubishi Chemical Group Company, where he was in charge of non-clinical research, corporate planning and PJ management of cell therapy product. After that, he took on responsibilities to develop the manufacturing process/analytical methods. From 2023, Keisuke moved on to PeptiDream, Inc. and was leading non-oncology pharmacology research including Myostatin inhibitor PJ for obesity treatment as a principal scientist. In April 2025, he joined Senno Therapeutics, Inc. as an associate director and is bringing his expertise in the manufacturing process/analytical methods development and PJ management.

Lisa Fox-Craig
CTO Lisa Fox-Craig

An accomplished cell and gene therapy professional with more than 30 years of experience in the development, cGMP manufacturing, and quality control for cell and gene therapy products. Successfully led development, manufacture and clinical delivery of ex vivo hematopoietic stem cells (HSCs), neural stem cells (NSCs), hepatic progenitor cells (HPC’s), activated T cells, gene-modified T cell & HSC products as well as in vivo adeno-associated virus (AAV) products. Lisa has held leadership roles at Orchard Therapeutics, Sangamo BioSciences, StemCells Inc, and Xcyte Therapies and has experience preparing CMC regulatory submissions with for cell and gene therapy submissions in the US, Canada, Japan, Switzerland and Europe.

Hideki Taniguchi
Scientific Founder and CSO Hideki Taniguchi

Professor and Director, Division of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo.
Dr. Taniguchi earned his Ph.D. in Medical Sciences from the Graduate School of Medical Sciences at the University of Tsukuba. After serving as Lecturer in Clinical Medicine (Gastroenterological Surgery) at the University of Tsukuba, he was appointed Professor of Organ Regenerative Medicine at Yokohama City University School of Medicine in 2002. Since 2018, he has been Professor in the Division of Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo. Beginning in 2019, he also took on the role of Director of the Center.
His expertise lies in regenerative medicine, stem cell biology, and transplant surgery. To address transplantation medicine’s most critical unresolved challenge—the absolute shortage of donor organs—he is strategically advancing the development of innovative therapies for liver diseases using human iPS cells.

Yusuke Wada
Corporate planning, Project Management Yusuke Wada

Over 15 years of drug discovery and development experience across small molecules, antibodies, and genetically engineered cell therapies through 15+ projects at Astellas Pharma, including novel target proposals, platform tech development, non-clinical POC, and external collaborations. Since 2018, led iPSC-based cell therapy R&D as Senior Scientist at Universal Cells. In 2024, joined Saisei Ventures as Senior Associate, driving deal sourcing, due diligence, technical strategy, and company creation. Founding member of Senno Therapeutics, supporting business strategy, product planning, and project management.

Directors

  • Chieko Mori

    Representative Director and CEO

    Chieko Mori
    Profile
  • Jonathan Yeh

    Chairman & Director

    Jonathan Yeh
    Profile
  • Hikaru Saito

    Board

    Hikaru Saito
    Profile